How do opioids affect the brain? They work by attaching themselves to the body’s opioid receptors. These receptors are found throughout our nervous systems. In other words? They’re everywhere. When you take an opioid and it binds with these receptors, it triggers endorphins that are responsible for pain relief or feelings of pleasure. This is a great thing for those who are managing extreme or chronic pain. Unfortunately, these opioid receptors are also found in the brain. Because of this, regular consumption of opioids is going to impact your brain health. Read on to learn more about common ways in which the mind is impacted by OUD.