Dr. Incavo and fellow researchers recently published, Drug Reaction with Eosinophilia and systemic Symptoms Syndrome after Total Knee Arthroplasty Infection and Placement of Antibiotic Spacer, in Arthroplasty Today. The research presents a rare case of a drug reaction complication after placement of an antibiotic-impregnated cement spacer. Antibiotic spacers placed during the first stage have been associated with a number of potential complications, including breakage, dislocation and allergic reactions.